β2-adrenoceptor (adrb2_human)
FAMILY
Class A (Rhodopsin) Aminergic receptors Adrenoceptors β2-adrenoceptor
GENE
ADRB2 (ADRB2R, B2AR)
ORGANISM
Human (Homo sapiens)
ALT. NAMES
Beta-2 adrenergic receptor, Beta-2 adrenoreceptor, Beta-2 adrenoceptor
SOURCE
SWISSPROT
SEQUENCE
N-term | |||||||||
M
|
G
|
Q
|
P
|
G
|
N
|
G
|
S
|
A
|
F
|
10 |
L
|
L
|
A
|
P
|
N
|
G
|
S
|
H
|
A
|
P
|
20 |
TM1 | |||||||||
D
|
H
|
D
|
V
|
T
|
Q
|
E
|
R
|
D
|
E
|
30 |
V
|
W
|
V
|
V
|
G
|
M
|
G
|
I
|
V
|
M
|
40 |
S
|
L
|
I
|
V
|
L
|
A
|
I
|
V
|
F
|
G
|
50 |
N
|
V
|
L
|
V
|
I
|
T
|
A
|
I
|
A
|
K
|
60 |
ICL1 | TM2 | ||||||||
F
|
E
|
R
|
L
|
Q
|
T
|
V
|
T
|
N
|
Y
|
70 |
F
|
I
|
T
|
S
|
L
|
A
|
C
|
A
|
D
|
L
|
80 |
V
|
M
|
G
|
L
|
A
|
V
|
V
|
P
|
F
|
G
|
90 |
A
|
A
|
H
|
I
|
L
|
M
|
K
|
M
|
W
|
T
|
100 |
ECL1 | TM3 | ||||||||
F
|
G
|
N
|
F
|
W
|
C
|
E
|
F
|
W
|
T
|
110 |
S
|
I
|
D
|
V
|
L
|
C
|
V
|
T
|
A
|
S
|
120 |
I
|
E
|
T
|
L
|
C
|
V
|
I
|
A
|
V
|
D
|
130 |
R
|
Y
|
F
|
A
|
I
|
T
|
S
|
P
|
F
|
K
|
140 |
ICL2 | TM4 | ||||||||
Y
|
Q
|
S
|
L
|
L
|
T
|
K
|
N
|
K
|
A
|
150 |
R
|
V
|
I
|
I
|
L
|
M
|
V
|
W
|
I
|
V
|
160 |
S
|
G
|
L
|
T
|
S
|
F
|
L
|
P
|
I
|
Q
|
170 |
ECL2 | |||||||||
M
|
H
|
W
|
Y
|
R
|
A
|
T
|
H
|
Q
|
E
|
180 |
A
|
I
|
N
|
C
|
Y
|
A
|
N
|
E
|
T
|
C
|
190 |
TM5 | |||||||||
C
|
D
|
F
|
F
|
T
|
N
|
Q
|
A
|
Y
|
A
|
200 |
I
|
A
|
S
|
S
|
I
|
V
|
S
|
F
|
Y
|
V
|
210 |
P
|
L
|
V
|
I
|
M
|
V
|
F
|
V
|
Y
|
S
|
220 |
R
|
V
|
F
|
Q
|
E
|
A
|
K
|
R
|
Q
|
L
|
230 |
Q
|
K
|
I
|
D
|
K
|
S
|
E
|
G
|
R
|
F
|
240 |
ICL3 | |||||||||
H
|
V
|
Q
|
N
|
L
|
S
|
Q
|
V
|
E
|
Q
|
250 |
D
|
G
|
R
|
T
|
G
|
H
|
G
|
L
|
R
|
R
|
260 |
TM6 | |||||||||
S
|
S
|
K
|
F
|
C
|
L
|
K
|
E
|
H
|
K
|
270 |
A
|
L
|
K
|
T
|
L
|
G
|
I
|
I
|
M
|
G
|
280 |
T
|
F
|
T
|
L
|
C
|
W
|
L
|
P
|
F
|
F
|
290 |
I
|
V
|
N
|
I
|
V
|
H
|
V
|
I
|
Q
|
D
|
300 |
ECL3 | TM7 | ||||||||
N
|
L
|
I
|
R
|
K
|
E
|
V
|
Y
|
I
|
L
|
310 |
L
|
N
|
W
|
I
|
G
|
Y
|
V
|
N
|
S
|
G
|
320 |
H8 | |||||||||
F
|
N
|
P
|
L
|
I
|
Y
|
C
|
R
|
S
|
P
|
330 |
D
|
F
|
R
|
I
|
A
|
F
|
Q
|
E
|
L
|
L
|
340 |
C-term | |||||||||
C
|
L
|
R
|
R
|
S
|
S
|
L
|
K
|
A
|
Y
|
350 |
G
|
N
|
G
|
Y
|
S
|
S
|
N
|
G
|
N
|
T
|
360 |
G
|
E
|
Q
|
S
|
G
|
Y
|
H
|
V
|
E
|
Q
|
370 |
E
|
K
|
E
|
N
|
K
|
L
|
L
|
C
|
E
|
D
|
380 |
L
|
P
|
G
|
T
|
E
|
D
|
F
|
V
|
G
|
H
|
390 |
Q
|
G
|
T
|
V
|
P
|
S
|
D
|
N
|
I
|
D
|
400 |
S
|
Q
|
G
|
R
|
N
|
C
|
S
|
T
|
N
|
D
|
410 |
S
|
L
|
L
|
DIAGRAMS
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
MUTATIONS
PHYSIOLOGICAL LIGANDS
L-NOREPINEPHRINE, (-)-adrenaline, noradrenaline, Zn2+, (-)-noradrenaline
STRUCTURE MODELS
STRUCTURES
Found 42 structure(s) - view all details on the Structures page
PDBs: 2RH1, 2R4R, 2R4S, 3D4S, 3KJ6, 3NY8, 3NY9, 3NYA, 3PDS, 3P0G, 3SN6, 4GBR, 4LDE, 4LDL, 4LDO, 4QKX, 5D5A, 5D5B, 5JQH, 5D6L, 5X7D, 6MXT, 6E67, 6N48, 6PRZ, 6PS0, 6PS1, 6PS2, 6PS3, 6PS4, 6PS5, 6PS6, 6NI3, 6OBA, 7BZ2, 7DHI, 7DHR, 7XKA, 7XK9, 8JJ8, 8JJL, 8JJO